life

CHOOSE HAPPINESS FIRST🌙

September 16, 2022May 13, 2023 - by srijeeta. - 1 Comment

Happiness isn’t something you simply wake up with one day. Happiness is something you have to choose, something to strive for, to work towards. you can wish for happiness, but …

Inspirational

Silence speaks 🌱

September 5, 2022September 5, 2022 - by srijeeta. - Leave a Comment

In a world that searches for new destinations and journeys… Between what I know and have forgotten and what I know not and struggle to remember You will find how …

English / Love

August 30, 2022August 30, 2022 - by Manas Halder - Leave a Comment

I walked through the dark lanes I have seen all kind of pains, Then I heard your voice I thought I can make a choice, When I saw you smile …

Love

Love is extinct… 🍂

August 25, 2022August 25, 2022 - by srijeeta. - Leave a Comment

Why do questions arise.. There’s a storm in my heart. The stars in the sky, Still looking for the shadows. My loved one appeared to be a stranger . I’m …

English

Nothing lasts

August 15, 2022 - by Manas Halder - Leave a Comment

A bud once appeared, It blossomed and spread fragrance, It would be withered; A star once shone up in the high, It emitted light, It would burn into ashes in …

Inspirational / mental health

Learn to live

August 3, 2022August 13, 2022 - by Manas Halder - 1 Comment

We keep on digesting things that we eat in every form, physical or mental. Life goes on with all the changes it could possibly adopt. Life is like water flowing …

Shayari

Random life

June 19, 2022 - by Manas Halder - Leave a Comment

Ocean is the life It’s still or it flows No one ever knows Try to swim fast, makes you tired Try to float, you might enjoy What it gives, takes …

Inspirational

On Living The Life You Want

June 18, 2022 - by Manas Halder - 1 Comment

Living the life you want to live comes down to determining what matters to you, what you want, and going after it. There’s nothing complicated about this existence once you …

Inspirational

How To Get Your Life Back On Track After A Setback

June 18, 2022 - by Manas Halder - 2 Comments.

If you’ve experienced a setback, here is what you need to know about how you can get your life back on track and move forward confidently. How To Get Your …

Inspirational / Spiritual

KARMA

April 5, 2022May 13, 2023 - by Manas Halder - Leave a Comment

Your KARMA is responsible for your happiness and sufferings. In Hinduism and Buddhism Karma is described as your actions in previous and or present life, which eventually decide your destiny. …

Inspirational / lifestyle / mental health / Science

What ! life !

April 3, 2022May 13, 2023 - by Manas Halder - Leave a Comment

A homeless, jobless, friendless Vagabond was looking for the answer to his question, what is life. He kept on moving from place to place and went on asking almost everyone …

Inspirational

Path

March 24, 2022May 13, 2023 - by Manas Halder - Leave a Comment

Many times you face the most difficult times in your life just because you had chosen a wrong path long time ago. You may cry, why me, but alas, you …

Inspirational / Science / Uncategorized

Don’t think Much

February 16, 2022February 16, 2022 - by Manas Halder - Leave a Comment

Don’t think much, ultimately you can’t change anything but youself. Do what you like, do what you love, do everything like you meant for it. There’s no better future than …

Science

How To Manage Stress The Healthy Way

May 30, 2021 - by Manas Halder - Leave a Comment

It is a proven fact that as humans, we need a certain amount of stress in our life to live – good stress if you will, something researchers call eustress. …

Short story / Uncategorized

The Girl With A Hidden Talent

April 14, 2021 - by Manas Halder - 1 Comment

Clutching her little notebook, she rushes onto the bus and scans her metro card. As she moves passing strangers, she finds an open seat and sits down next to the …

Uncategorized

Experimental miracles

April 12, 2021 - by Manas Halder - Leave a Comment

Yes, we all want a life full of happiness, positivity, serenity, positive events and miracles. We do expect miracles in our lifetime especially if something dreadful, devastating or unexpected is …

Science / Uncategorized

#462 Discipline – S2 E6 – The Process – Why routines work

April 1, 2021 - by Manas Halder - 1 Comment

I am more than convinced that you can become the most motivated person that has ever lived on this planet! Ok, maybe the second most motivated person right next to …

Uncategorized

Grateful for Friends, Faith and Freedom!!!

March 28, 2021 - by Manas Halder - Leave a Comment

I have been having a great time watching the World Cup games. Watching Brazil’s game last Saturday almost gave me heart attack. I keep telling myself it is just a …

Creating a Conducive Learning Atmosphere: Tips for Dressing, Scheduling, and Designing Your Homeschool ClassroomMay 29, 2023
Creating a conducive learning atmosphere with these essential homeschooling tips. From dressing for success to establishing schedules and rules, discover the keys to a successful at-home classroom.
Eight Reasons Why Your Child Hates ReadingMay 28, 2023
Discover the reasons why your child may hate reading and learn how to ignite their love for books! Find tips on selecting age-appropriate books, creating positive environments, and more
Alcohol As a Food: Experts Unanimously Agree on Its Lack of Nutritional ValueMay 21, 2023
Learn why alcohol cannot be considered a food and how it lacks essential qualities to contribute to the nutrition of the body. Discover the findings of thorough studies and experiments by medical experts on the role of alcohol as a constructive agent. Experts Unanimously Agree on Its Lack of Nutritional Value.
Effect Of Alcohol on WomenMay 20, 2023
Discover the truth behind the commonly accepted myth that women have a lower alcohol tolerance than men. Learn about the complex effects of alcohol on the body and mind and how to practice responsible drinking for a safer and more enjoyable experience
The Devastating Effects of Excessive Alcohol Consumption on Internal OrgansMay 18, 2023
Alcohol can have various effects on internal organs when consumed in excessive amounts or over a prolonged period. Here are some of the devastating effects of excessive alcohol consumption on internal organs:
5 Reasons Why Alcohol Will Destroy Your Muscle GainsMay 18, 2023
It is crucial to recognize the significant harm caused by alcohol, which often goes underestimated. Understanding the impact of this drug (yes, alcohol is classified as a drug) on your overall progress, both within and outside the gym, is of utmost importance.
How Smoking Tricks Your Brain into Believing It’s a Stress RelieverMay 14, 2023
When you were a teenager, your friends maybe started smoking, and all of them want you to smoke with them. They make fun of you because you don't want to smoke, and they're generally giving you a hard time. Every day. Some kids resist, but others may cave in to peer pressure. They finally break down and start smoking.When you do, here’s the process: Most people say that they smoke to release stress. Especially when they get really anxious or really wound up about some…
How to Handle Family Disagreements as an AdultMay 9, 2023
When you were younger do you remember having disagreements with your family, namely your parents or your siblings? As you increase in age, there is a good chance that many …
Adult Autism: Growing Old with AutismMay 3, 2023
For many people adult autism is just the way of life. They have to endure living with this disorder, which can be very difficult because they can't function as normal people can function. For some people, they have learned to accept this disorder and live with it, but what makes it really difficult for some is how those around them treat them and society in general. As a society, we should try our best to study and learn and understand what adult autism is and not just fo…
Adult ADD/ADHD: Eat to LiveMay 2, 2023
Being healthy isn't easy, and if you have adult ADD, you may be skipping over this part entirely. You probably forget to eat meals and just grab whatever candy bar or fast-food snack is at hand. You need to remember one thing, though. If you don't eat, you die. It's as simple as that. So, even if you have to be led to the banquet table, you have to remember that healthy meals are not an option. It's not that hard to eat things that are good for you, even if you have adult …

Creating a Conducive Learning Atmosphere: Tips for Dressing, Scheduling, and Designing Your Homeschool Classroom
Creating a conducive learning atmosphere with these essential homeschooling tips. From dressing for success to establishing schedules and rules, discover the keys to a successful at-home classroom.
Eight Reasons Why Your Child Hates Reading
Discover the reasons why your child may hate reading and learn how to ignite their love for books! Find tips on selecting age-appropriate books, creating positive environments, and more
Alcohol As a Food: Experts Unanimously Agree on Its Lack of Nutritional Value
Learn why alcohol cannot be considered a food and how it lacks essential qualities to contribute to the nutrition of the body. Discover the findings of thorough studies and experiments by medical experts on the role of alcohol as a constructive agent. Experts Unanimously Agree on Its Lack of Nutritional Value.
Effect Of Alcohol on Women
Discover the truth behind the commonly accepted myth that women have a lower alcohol tolerance than men. Learn about the complex effects of alcohol on the body and mind and how to practice responsible drinking for a safer and more enjoyable experience
The Devastating Effects of Excessive Alcohol Consumption on Internal Organs
Alcohol can have various effects on internal organs when consumed in excessive amounts or over a prolonged period. Here are some of the devastating effects of excessive alcohol consumption on internal organs:
5 Reasons Why Alcohol Will Destroy Your Muscle Gains
It is crucial to recognize the significant harm caused by alcohol, which often goes underestimated. Understanding the impact of this drug (yes, alcohol is classified as a drug) on your overall progress, both within and outside the gym, is of utmost importance.
How to Handle Family Disagreements as an Adult
When you were younger do you remember having disagreements with your family, namely your parents or your siblings? As you increase in age, there is a good chance that many of those arguments and disagreements disappeared, but, in adulthood, you may see them reappear. If and when the time comes, do you know what to do? Unfortunately, many women are unsure as to where they should stand or how to handle this important issue of how to handle family disagreements as an adult. It is important to realize that there is a difference between your partner and the family that you grew up with. Photo by Afif Ramdhasuma on Pexels.com With romantic partner When it comes to adulthood problems with family members, many women automatically think of problems that they have with their husbands or their romantic partners. While these are complications and issues that need to be dealt with, it is important to realize that there is a difference between your partner and the family that you grew up with. That is why it is important that you handle those situations and issues differently. With the siblings One of the many problems that women have to deal with, concerning their family in adulthood, is that of sibling rivalries. This is particularly common if you come from a family with three or more children. If one of your siblings is having disagreements with another one, there is a good chance that you may be pulled into the middle. If, at all costs, you are advised to try to stay out of it. There is nothing trickier than having to choose between one sibling and another, especially in adulthood. Although you may not think about it at the time, this is when many families experience rifts that cannot be repaired. With the parents When parents go for divorce, we often think of young children having to deal with the ramifications of divorce. With that in mind, the problems can be just as bad, if not worse, when everyone is an adult. Photo by cottonbro studio on Pexels.com Another situation that many women are placed in is between disagreements or, in worst case scenarios, divorces between their parents. When parents go for divorce, we often think of young children having to deal with the ramifications of divorce. With that in mind, the problems can be just as bad, if not worse, when everyone is an adult. In messy divorces, it is not uncommon for one parent to expect their adult children to support them and them alone. While you have complete control over your decisions, it is important, like with your sibling rivalries, that you stay as neutral as possible. The last thing that you want to do is cause a rift between you and your parents, especially when you may not have all the time in the world to repair that rift. What to do & Why Although it is nice to hear that you should avoid any family complications in adulthood, at all costs, you may be feeling pressured. If that is the case, it is important that you explain your feelings to your family members. After all, they spent their lives either raising you or growing up with you. This means that they should understand where you are coming from. Simply ask your brother, sister, mother, or father to put themselves in your shoes and image how you are feeling. If that does not do the trick, it may be a good idea to seek assistance from a professional counselor. Take home As a reminder, you have the ability to handle any family issues that come your way, any way that you see fit. With that in mind, it is important that you use your best judgment. Unlike when you were a child or a teenager, you may not be able to get a quick fix. With no guarantees on how much time you, your parents, or your siblings have left, why take that chance?
Male “Menopause” – The Alternative Anti-Aging Approach
If you are a male over the age of 40 and are suffering from weakness, impotence, pain, stiffness, drooping muscles, depression, anxiety, or heat intolerance, you may be experiencing “andropause”. Andropause is a syndrome resulting from the deficiency of hormones, especially testosterone. It’s onset and symptoms may not be as dramatic as female “menopause”, but its effects can be just as serious. It is interesting that hormone replacement is quite routine in women but barel…
An Introduction to Radio Astronomy
For most of us, the idea of astronomy is something we directly connect to “stargazing”, telescopes and seeing magnificent displays in the heavens. And to be sure, that is the exciting area of astronomy that accounts for its huge popularity. So, to the uninitiated, the idea of “radio astronomy” seems strange. There are two reasons for that. First is that humans are far more visual than audio oriented. And the second is that radio astronomy doesn’t really involve “listening” to the cosmos except to the extent that scientists who use this sophisticated form of “stargazing” do not rely on visual study to conduct their work.
How to Use Sun Energy without Solar Panels
You’ve grown tired of paying monstrous electric bills and have decided to go solar. Solar panels, however, aren’t exactly to your taste. Don’t worry, you can go solar without them.

Creating a Conducive Learning Atmosphere: Tips for Dressing, Scheduling, and Designing Your Homeschool Classroom
Creating a conducive learning atmosphere with these essential homeschooling tips. From dressing for success to establishing schedules and rules, discover the keys to a successful at-home classroom.
children education homeschool Social
Eight Reasons Why Your Child Hates Reading
Discover the reasons why your child may hate reading and learn how to ignite their love for books! Find tips on selecting age-appropriate books, creating positive environments, and more
child hates reading children reading book Social
How Smoking Tricks Your Brain into Believing It’s a Stress Reliever
When you were a teenager, your friends maybe started smoking, and all of them want you to smoke with them. They make fun of you because you don’t want to smoke, and they’re generally giving you a hard time. Every day. Some kids resist, but others may cave in to peer pressure. They finally break down and start smoking. When you do, here’s the process: Most people say that they smoke to release stress. Especially when they get really anxious or really wound up about some…
ADD ADD support ADHD attention deficit treatment
How to Handle Family Disagreements as an Adult
When you were younger do you remember having disagreements with your family, namely your parents or your siblings? As you increase in age, there is a good chance that many of those arguments and disagreements disappeared, but, in adulthood, you may see them reappear. If and when the time comes, do you know what to do? Unfortunately, many women are unsure as to where they should stand or how to handle this important issue of how to handle family disagreements as an adult. It is important to realize that there is a difference between your partner and the family that you grew up with. Photo by Afif Ramdhasuma on Pexels.com With romantic partner When it comes to adulthood problems with family members, many women automatically think of problems that they have with their husbands or their romantic partners. While these are complications and issues that need to be dealt with, it is important to realize that there is a difference between your partner and the family that you grew up with. That is why it is important that you handle those situations and issues differently. With the siblings One of the many problems that women have to deal with, concerning their family in adulthood, is that of sibling rivalries. This is particularly common if you come from a family with three or more children. If one of your siblings is having disagreements with another one, there is a good chance that you may be pulled into the middle. If, at all costs, you are advised to try to stay out of it. There is nothing trickier than having to choose between one sibling and another, especially in adulthood. Although you may not think about it at the time, this is when many families experience rifts that cannot be repaired. With the parents When parents go for divorce, we often think of young children having to deal with the ramifications of divorce. With that in mind, the problems can be just as bad, if not worse, when everyone is an adult. Photo by cottonbro studio on Pexels.com Another situation that many women are placed in is between disagreements or, in worst case scenarios, divorces between their parents. When parents go for divorce, we often think of young children having to deal with the ramifications of divorce. With that in mind, the problems can be just as bad, if not worse, when everyone is an adult. In messy divorces, it is not uncommon for one parent to expect their adult children to support them and them alone. While you have complete control over your decisions, it is important, like with your sibling rivalries, that you stay as neutral as possible. The last thing that you want to do is cause a rift between you and your parents, especially when you may not have all the time in the world to repair that rift. What to do & Why Although it is nice to hear that you should avoid any family complications in adulthood, at all costs, you may be feeling pressured. If that is the case, it is important that you explain your feelings to your family members. After all, they spent their lives either raising you or growing up with you. This means that they should understand where you are coming from. Simply ask your brother, sister, mother, or father to put themselves in your shoes and image how you are feeling. If that does not do the trick, it may be a good idea to seek assistance from a professional counselor. Take home As a reminder, you have the ability to handle any family issues that come your way, any way that you see fit. With that in mind, it is important that you use your best judgment. Unlike when you were a child or a teenager, you may not be able to get a quick fix. With no guarantees on how much time you, your parents, or your siblings have left, why take that chance?
adult disagreements as an adult divorce family parents Social
Adult Autism: Growing Old with Autism
For many people adult autism is just the way of life. They have to endure living with this disorder, which can be very difficult because they can’t function as normal people can function. For some people, they have learned to accept this disorder and live with it, but what makes it really difficult for some is how those around them treat them and society in general. As a society, we should try our best to study and learn and understand what adult autism is and not just fo…
adult Autism
Adult ADD/ADHD: Eat to Live
Being healthy isn’t easy, and if you have adult ADD, you may be skipping over this part entirely. You probably forget to eat meals and just grab whatever candy bar or fast-food snack is at hand. You need to remember one thing, though. If you don’t eat, you die. It’s as simple as that. So, even if you have to be led to the banquet table, you have to remember that healthy meals are not an option. It’s not that hard to eat things that are good for you, even if you have adult …
adult ADD adult ADHD attention deficit hyperactivity disorder
Are Narcissists addicted to being famous?
As far as their fans are concerned, celebrities fulfil two emotional functions: they provide a mythical narrative (a story that the fan can follow and identify with) and they function as blank screens onto which the fans project their dreams, hopes, fears, plans, values, and desires (wish fulfilment).
control ego famous narcissist Psychology satisfaction Social
The Killer Truth
Humans, the most creative and imaginative creatures on earth are driven by their psychological state of mind. They hardly analyze the observed fact but are prone to create a virtual idea of his observations and act accordingly. However, this quality does separate them from the other living organisms on the planet.
art friends inner self isolation maturity Psychology selfishness Social solitude
Can Online Education Replace Classrooms?
Today, the internet is widely regarded as a major bridge linking the small and big, the possible and impossible, hidden and open and creating extensive possibilities across a wide spectrum. It strategically empowers the small guy to set up home-based business and pose like a giant concern. Even charities organizations are now thriving better through application of Internet resources.
classroom education Classrooms Discounts distance education e-learning education internet Psychology Social
Effects Of Cannabis Addiction
Cannabis is a plant that we commonly call marijuana, ganja in herbal form or hashish in resinous form. It has been commonly used way back prehistoric times. However, its use became prevalent in the 20th century when cannabis was utilized for religious, spiritual, medicinal and even recreational purposes. It was then that its possession, use or sale was prohibited. To date, the use of cannabis for drug use or cannabis addiction remains illegal all throughout the most parts of …
and eithefeeling of intense pleasureanxiety cannabis cannabis addiiction emphysema euphoria ganja grass hashish increased appreciation for music intense relaxation laughter and giggle fits lung cancer Marijuana spiritual talking stop cannabis smoking

Effect Of Alcohol on Women
Discover the truth behind the commonly accepted myth that women have a lower alcohol tolerance than men. Learn about the complex effects of alcohol on the body and mind and how to practice responsible drinking for a safer and more enjoyable experience
affects of alcohol on women alcohol drunkeness Health safe drinking Social women and alcohol
The Devastating Effects of Excessive Alcohol Consumption on Internal Organs
Alcohol can have various effects on internal organs when consumed in excessive amounts or over a prolonged period. Here are some of the devastating effects of excessive alcohol consumption on internal organs:
alcohol brain effects of alcohol heaert Health liver Social stomach
Male “Menopause” – The Alternative Anti-Aging Approach
If you are a male over the age of 40 and are suffering from weakness, impotence, pain, stiffness, drooping muscles, depression, anxiety, or heat intolerance, you may be experiencing “andropause”. Andropause is a syndrome resulting from the deficiency of hormones, especially testosterone. It’s onset and symptoms may not be as dramatic as female “menopause”, but its effects can be just as serious. It is interesting that hormone replacement is quite routine in women but barel…
anti-aging antiaging clinic Health male male menopause menopause Social treatment
What are the advantages of an air-purifier?
Do you own an air purifier? If not, there is a good chance that you would be interested in owning one in the future, if you aren’t already interested. That is because air purifiers are rapidly increasing in popularity. What are the advantages of an air-purifier? They are rapidly increasing in popularity because they make indoor air healthier and cleaner. This means that by owning an air purifier, your home or your office space could become a pleasant place to be, instead of an unhealthy or an unpleasant place.
Activated Carbon Air Purifiers air purifier Air-To-Air Exchangers Central Air Cleaners clean air cost effective Electronic Air Cleaners Health HEPA Air Purifiers HEPA filter Ionic Air Purifiers Social Ultraviolet Air Purifiers UPS
Eating Healthy on Vacation
It can be very tempting to abandon your good sense of eating healthy on vacation. Although you may strive for healthy eating, it’s easy to drift off and grab an ice cream cone here and there. There are, however, ways to watch what you eat on vacation. When traveling A woman in black blazer sitting inside the airplane going to order for her vegetarian meal- eating healthy on vacation – The Scorpion. Photo by RODNAE Productions on Pexels.com It’s easier than ever these days to request a low fat or vegetarian meal on airplane flights. If you choose to instead drive to your destination, the quest to find healthy food can get a bit more complicated. Rather than simply relying on greasy foods for nutrition, pack some nutritious foods in a cooler full of ice packs. Fruits and vegetables, crackers, yogurt, and sandwiches are all great to have with you on the road. In the hotel Once you arrive at your hotel, you should do yourself a favor and turn the minibar key down – as this helps to avoid the temptation. If your hotel offers a continental breakfast, stick to fruits, cereals, and proteins. When your hotel has a stove or microwave, consider bringing your own healthy food with you. If you simply must eat out, do so only when you are hungry. Restaurants will usually serve large portions, so be careful. If you do go a bit over on a meal, simply cut back on the next. If you find it hard to fit in three square meals a day, try to fit in six smaller meals or snacks, as your body needs fuel every four hours or so. When you eat out, avoid appetizers. Whatever you do, do not miss any meals. Bowl of vegetable salad and sliced fruits, a healthy food- eating healthy on vacation – The Scorpion. Photo by Jane Doan on Pexels.com When it’s possible, you should avoid eating large meals at night. When your body gets ready for sleep and slows down, it also burns calories at a much slower pace. Never eat bread before bed, and make sure to avoid the butter. Choose fish or poultry for your meal instead, and include vegetables as a side dish. Take this advice Even though it may sound hard, eating healthy on vacation isn’t really that difficult. All you have to do is use a little willpower, and pass up foods that you know aren’t good for you. This way, you’ll enjoy healthy eating and a healthy lifestyle wherever you go. The next time you go on a vacation, always remember that eating healthily is a way of life. You can afford to get something you crave, although you shouldn’t make a habit of it. One ice cream cone or a pizza isn’t going to matter – as long as you know when to stop.
breakfast cereals crackers eating healthy on vacation Health healthy food nutritious food poltry protein sandwiches vacation vegetables yohurt
COMMUNICATION 🌤
Optical, auditory, emotional, nonverbal, and verbal types of communications are needed to continue a relationship. A little communication goes such a long way. A relationship should be based on communication not on assumptions. Touch helps to create bonds! Maupassant said “It is the encounters with people that make life worth living.” A willingness to communicate without blame and stick to the point, being able to express anger assertively without blame or making the other person wrong and also respect differences without expressing judgement are the key to communicate with others positively. Physical touch and expression of affection are also a part of communication that should be mutually enjoyable. Sometimes a hug is all that you need to make you feel better. It can also be a sign of security, emotional support, friendship, or love. When you hug your partner you immediately give them the benefit of boosting their oxytocin levels, which creates a stronger bond and connection between the huggers. It is proved that oxytocin can boost the immune system ,reduce the stress hormone norepinephrine thus reduce stress and blood pressure. When you hug for several moments you can lift the level of serotonin. This can improve your partner’s mood. So a simple hug can reduce the feelings of loneliness, isolation and anger . When you hug there is an easy pressure that is placed on the sternum which creates an emotional charge activating the solar plexus, stimulating the thymus gland, which takes care of body’s production of the white blood cells and those keep a person free from disease and healthy. So A hug a day keeps the doctor away. Virginia Satir once said, We need four hugs a day for survival. We need 8 hugs a day for maintenance. We need 12 hugs a day for growth. Touch can calm your nerves, lowers cortisol levels. Cortisol causes things like fat gain, heart disease, and high blood pressure, so physical touch isn’t just calming, but also healthy. While Hugs can make angry people comfortable, Holding your partner can offer comfort in crisis. Logically, trust is built over time when a couple gets to know one another’s true loyalty, patterns of behavior. In our brain sense of trust is often triggered by the release of dopamine. This neurotransmitter is responsible for feeling closer to your partner through promoting trust and happiness. Physical intimacy also releases the endorphin which can act as a natural painkiller in our system. It can bring joy to your tough day and help you get a break from the negative thoughts. When polarity in relationships is fully embraced, a beautiful connection is created. So a little communication goes a long way. If you’re busy say it, if you’re running late then let people know, if you don’t want to do something, be straightforward, if you’ve doubt then ask.
affection benefit brain communication Health hormones hug medical Psychology security Social touch
Vaccines and Drugs for COVID-19: An overview
2020 was a pandemic year in human civilization that has affected 220 countries and resulted in 1.4 million deaths so far. This pandemic was the outcome of infection caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) that accounted for 63 million confirmed human infections (World Health Organization (WHO)). The highly pathogenic virus strain was first reported in Wuhan, China in December 2019 leading to coronavirus disease 2019 (COVID-19). Highly pathogenic SARS- CoV2 is an enveloped, single-stranded RNA virus of Coronaviridae family, which encode non-structural proteins (nsps), structural proteins, and several accessory proteins. Being a respiratory virus, primarily transmitted through aerosol and contact, it affected mainly the respiratory tract but Brain, Liver and Kidney have also been reported to be secondarily damaged. To fight the pandemic an effective vaccine or drug is urgently needed. Several licensed coronavirus (CoV) vaccines are available for domestic animals but not for humans. Two vaccine candidates for SARS- CoV and three for MERS- CoV are in phase I clinical trials (WHO). A successful vaccine must elicit both humoral and cellular immunity with immunologic memory. It must evoke immune response within the incubation period. Also, it must evoke humoral response against conserved coat proteins. However, an improper vaccine has potential risks of enhancement of the disease through antibody- dependent enhancement (ADE) mediated by non-neutralizing virus binding antibodies or enhanced respiratory disease (ERD) mediated by our own biased immune cell T helper 2 (TH2). It must be noted that already infected patients must be given specific drugs to get rid of the virus and vaccines have no use for them. Vaccines provide life-long immunity to normal uninfected persons through repeated exposure by developing immunologic memory. All CoV enzymes and proteins involved in viral replication and the control of host cellular machineries are potential drug targets to be used as therapeutic agents for SARS- CoV-2. There are a number of drugs with activity, currently being investigated against virus-based and host-based targets. Vaccines for SARS- CoV-2 Out of more than 214 COVID-19 vaccines, 51 are in clinical trials, 13 of them in phase III trials and several ready for field use (WHO; COVID-19 Vaccine tracker). There are three broad categories of candidate vaccines – first, protein- based vaccines such as inactivated virus vaccines, virus- like particles and protein subunit vaccines; second, gene- based vaccines such as virus- vectored vaccines, DNA vaccines and mRNA vaccines; and, third, a combination of both protein- based and gene- based vaccines such as live- attenuated virus vaccines. Hence, seven types of vaccines are being evaluated for potential use against COVID-19. These are summarized in the following table: Vaccine targets of SARS- CoV-2 SARS- CoV-2 encodes four structural (spike (S), membrane (M), envelope (E) and nucleocapsid (N)), 16 non-structural (nsp1-16) and 9 accessory proteins. All of these are potentially immunogenic and may be used to generate vaccines. However, S protein is the main target for vaccine development as it is involved in host cell receptor binding and membrane fusion and it’s a large protein having highly immunogenic epitopes. Thirteen vaccines against “S” protein are currently being developed and out of them 8 are in Phase III trials like Oxford-AstraZeneca, Moderna, BioNTech-Pfizer, Novavax, Janssen etc. These vaccines use full length S protein with or without some substitutions or the receptor binding domain (RBD) as immunogen. Unlike S protein, M and E are poorly immunogenic due to their small molecular size. Hence, no vaccine is currently being developed using these proteins. On the other hand N protein is highly immunogenic but it has been reported that vaccine expressing N protein enhanced infection- induced pneumonia and ERD. Other than targeting a specific protein, whole UV, heat or chemically inactivated viruses are also being used to generate vaccines. Inactivated viruses contain all structural coat proteins, hence, they induce a broader antibody and T cell responses. Currently 4 inactivated virus vaccines are being developed and 3 of them are in phase III clinical trials (Sinovac, Sinopharm etc.). Drugs for SARS- CoV-2 Structure-based therapeutic drugs are being designed (some with computational studies) against SARS- CoV-2 structural (S, E, M and N) and non-structural (nsp1-16) proteins and also against host proteins that are crucial for virus life cycle. These proteins are pharmacological targets of specific therapeutic compounds or ligands due to their critical function in viral transcription and replication. Drugs inactivate specific proteins by binding with specific amino acids or domains on them. Several drugs, effective against other diseases, are currently being analyzed and considered or repurposed in CoV treatment. Following table represents drug targets with experimentally potential compounds against CoV proteins— Some of these potential drugs are in clinical trials for their efficacy. Apart from targeting key viral proteins, host cell factors are also being analyzed as potential drug targets to curb infection. These host factors regulate viral entry and inflammatory responses. Some of the anti-host drugs are under clinical trials – Some drugs have already been proven effective in clinical trials and got approval like Galidesivir, Chlorpromazine, Triflupromazine, Resveratrol, Gemcitabine, Mefloquine, Loperamide, Ivermectin, Losartan, Chloroquine, and Hydroxycholoquine. Finally, it should be noted that combination therapeutic approach is more promising to evade viral mutation escape. Though drug repurposing giving hope, an effective vaccine and novel multi-targetable drugs must be developed for current as well as future epidemic re-emergence. References: Bloch, E. M. et al. J. Clin. Invest. 130, 2757–2765 (2020).Burrage, D. R., Koushesh, S. & Sofat, N. Front. Immunol. 11, 1844 (2020).Cai, Y. et al. Science 369, 1586–1592 (2020).Chi, X. et al. Science 369, 650–655 (2020).Dai, L., Gao, G.F. Nat. Rev. Immunol. (2020).Fung, M. et al. Transpl. Infect. Dis.(2020).Gao, Q. et al. Science 369, 77–81 (2020).Gil, C. et al. J. Med. Chem. 63, 12359−12386 (2020).Graham, B. S. Science 368, 945–946 (2020).Hueso, T. et al. Blood 136, 2290–2295 (2020).Le, T. T. Nat. Rev. Drug. Discov. 19, 305-306 (2020).Lee, W. S., Wheatley, A. K., Kent, S. J. & DeKosky, B. J. Nat. Microbiol. 5, 1185–1191 (2020).Liu, X., Cao, W. & Li, T. Front. Immunol. 11, 1660 (2020).McKee, D. L. et al. […]
Chloroquine Corona virus Covid-19 Drug development Health Infectious diseases medical pandemic redemies respiratory disease. SARS-CoV2 Spike protein Vaccine

The Killer Truth
Humans, the most creative and imaginative creatures on earth are driven by their psychological state of mind. They hardly analyze the observed fact but are prone to create a virtual idea of his observations and act accordingly. However, this quality does separate them from the other living organisms on the planet.
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Have Sense
Have Sense and live a meaningful life. The meaning of life do vary from person to person.
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Tell Me more
Tell me what’s your name, If I heard it before
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Baag ke phool
Another funny 🤣 poetry in same broken Hindi. What it says that one day a honey bee asked a gardener if he would allow him inside, but he denied permission saying he was not trustworthy. On another day a goat came and asked the gardener if he could go inside. The gardener thought it’s a poor goat, so he allowed him inside. The goat was a fool, he didn’t understand the value of flowers so he ate all the leaves and destroyed all the flowers. The gardener became upset that his beautiful garden was spoilt by a goat who didn’t even pay a penny as a compensation. The gardener thought may be the Bee would be better.
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Monday Blues
I loved once And screwed manies, I lived my life; Spilled all my pennies! I dived into the ocean Touched the bottom, I found a shell; But there was no gem! I went in woods Hoped to find some food; Looked at all the branches There was no fruit! I dug the ground When I felt thirsty; I caught a flow; but It wasn’t tasty! I felt little horny Went to see mate; I found a lot Who were full of hate! I felt sleepy, Got a sweet dream; Wished to see the end; but The dawn pulled the curtain! I realized wht life is Got confused – to live or to die; I changed my point of view Then the world felt shy!
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To Love
To Love one who loves you, to admire one who admires you, in a word, to be the idol of one’s idol, is exceeding the limit of human joy; it is stealing fire from heaven. By Mad. De Girardin
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MYSELF 💙
She is a girl with dreams in her eyes A hope to fly, to touch the sky. Behind those eyes mysterily hide millions of feelings. She is held by her own gravity. Negativity is the enemy of her creativity. She forgets where she puts her hair clips But she remember every small thing about him. She’s careless, but she cares about alot for him She believes in kindness and the magic of fragrance, She lives in the universe with comet and nebula, And Dancing with the galaxies. This little girl who once thought darkness was the home of demons, Now the young girl can’t stop herself from falling in love with the darkness. This little girl who had nycotophobia Now she’s suffering from nyctophilia. She thinks a lot, but doesn’t speak to much, Nobody listened to her when she had a lot to say. But she’s a crazy story teller to her love. She’s a good listener, she loves being philosophical. She doesn’t need money, one day she earns enough for herself. She doesn’t need social status, she knows her own value. She doesn’t need expensive dinner, neither diamond nor gold, She just needs one shoulder to cry on when life gets hard on her. She’s poor and has nothing but a cup of black coffee with a little sugar, She’s a believer, who loves the smell of books, She’s a thinker, who loves to play guitar creating her own notes. She’s not pretty but has the ability to make others smile, Even when she’s sad. She is not anyone’s first priority, she is only an option. When everyone has to make a choice between her and the other person, No one will choose her first. One day she will build a kingdom by her own desires. She hates waiting for someone, But she can wait for a lifetime. At the end she sleeps alone with her dream!
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The Floral Heart ♠
You are the love that came without warning, And before i knew it, I was falling in love with you. My love happens unintentionally in a single flashing moment. It is not love at first sight. It is about the best kind of chemistry between two people when they meet. My nights pass somewhere and mornings elsewhere. This feeling in my heart keeps on increasing, it will surely render me crazy. How did you become so essential to me. You will imagine all the things ,that you will do one day, For that person you will bleed, for that person you’ll pray. In the direction where your breaths move, I wish i’ll stay there for my entire life. I fall in love with the most unexpected person, And he is the most beautiful thing i keep inside my heart. The first time I saw you I knew you’d be mine, I fall in love with the same person everyday. But it is not love at first sight, For me it is love at every single sight. I wish we stay the same, this much in love this much close, I wish to kiss your all tears , before in your eyes they froze.
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MIO AMORE 💖
He never liked me in fancy clothes, dark lipstick, perfect hair, high heels or an edited picture. Instead he compliments me in my natural and real form of messed up hairs, simple dressing and a big smile on my face. Yes he!! He’s a rare wildflower, a flower that enlightens my inner soul. His sweet fragrance freshens me, while his presence brightens me. He is doing normal conversation with me, And I’m going deep in his love by listening his every single word. When his words fall silent,my heart still hears his voice. Everywhere I look I only wish to see him. Once I told him take me dear before I die, Or look at me and forever say goodbye. I saw something in you that I couldn’t live without. I may speak rubbish,but you’re the only person I share those with. The life you scripted for me is more beautiful than any of the dreams I weave. To cross paths with someone who makes it easier. I don’t know whether your eyes or talks were the reason, That a day without talking to you feels like a year. I want to hold your hand when we’re 80 and say we made it. Yes he….
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CHOOSE HAPPINESS FIRST🌙
Happiness isn’t something you simply wake up with one day. Happiness is something you have to choose, something to strive for, to work towards. you can wish for happiness, but if you rarely make choices that align with your idea of happiness, you will never truly fill it. Accept that there will be some testing moments and try a little harder to honor yourself and make decisions that better your life and also your mental state. Show up for yourself first , so you can show up for others. Remember that you have to choose happiness, it doesn’t always choose you. So stay true to your idea of happiness and make a point of doing things (no matter how small they may seem) each day to help you achieve it. The best kind of people are the ones who love you unconditionally, are soft and gentle with your heart and soul, take responsibility for their actions, respect other members of your family let you be yourself and accept you as you are , forgive others instead of seek revenge, patient with your struggles, help you without expecting anything in return, listen attentively, ask you to message them when you get home safe, check up on you when you are quiet, see the best in you even when you can’t, find happiness in your happiness, don’t try to make you feel guilty for being upset, are always honest, kind and loyal, hold space for you to feel your feelings without judgement. Some things you probably won’t regret are -doing more study, reading more and more books, being more honest, following your passion (such as painting or poetry), being kind to a stranger, finding your purpose, taking a break when you need one, sometimes listening to your brain, just to save your heart, taking care of your mental health, letting go of toxic people, loving yourself more and more. A bad relationship is like standing on broken glass, if you stay you will keep hurting dear and if you walk away you will also hurt but eventually you will heal. Ask yourself what you want your life to look like, close your eyes and try to picture yourself living your happiest life to the highest potential. Notice what surrounds you, who surrounds you. Notice what you have and what you bravely left behind to get to this place of peace. Now think about the present moment and ask yourself if the life you are living now will eventually lead you to the life you were just imagining for yourself. And if the answer is no, ask yourself what you could do differently. Sometimes you have to let people go because in the ocean of life when all you’re trying to do is stay afloat, they’re the anchor that’s drowning you. We are often let down by those we trusted and loved by the most unexpected ones. Some make us cry for things that we haven’t done, others ignore our faults and just see our smile, some leave us when we need them most, some stay with us when we ask them to leave. The world is a mixture of people, we just need to know which hand to shake and which hand to hold. You have only one life to live, so live it without worrying about what others may think about you. In the end we only regret the chances we didn’t take. Apparently we actually live two lives. The second one starts when we realise we only have one. Love the one who loves you back unconditionally not your bank balance, big house or cars , don’t waste it on those that only love you when the conditions are right for them. A relationship doesn’t solely belong to one person. No matter how hard you try. If the feeling is not mutual , it’ll be fruitless. And if the feelings are mutual the effort will be equal. Remember “Understanding” is an art and not everyone is an artist. You don’t love someone who wants your money, materialistic things and whatever. To live is the rarest thing in the world. Most people just exist that’s all. So be the rare one, have fun, fall in love again, regret nothing, and don’t let people bring you down. Right decisions determine the direction of your destiny. The right decisions are always the hardest to make, but they must be made in order to live the life you deserve.
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